The positive brain health now study is a prospective cohort study. We will accrue our population through consecutive sampling from five clinics: in Montreal, the Chronic Viral Illness Service at the Montreal Chest Institute, McGill University Health Centre and Clinique Médicale l’Actuel, a large primary care and HIV clinic; in Vancouver: the AIDS Research Program (at St Paul’s Hospital); in Hamilton, Special Immunology Services Clinic, and in Toronto, Maple Leaf Medical Clinic.
A total of 900 participants (150-300 per clinic) will be comprehensively assessed and followed longitudinal at 9 month intervals over a 27 months period for a total of 4 assessments (5 assessments if participant is selected to have neurocognitive evaluation).
- Age ≥ 35 (If necessary, we will oversample patients > 60 years old and women to ensure at least 100 of each are enrolled)
- HIV+ for at least 1 year
- Able to communicate adequately in either French or English
- Able to give written informed consent
- Dementia as defined by MSK-rating stage 3 or more- cognitive component only
- Concern about capacity to consent
- Life expectancy of < 3 years or other personal factor limiting the ability to participate in follow-up
- HIV and non HIV related neurological disorder likely to affect cognition,
- Known active CNS opportunistic infection or hepatitis C requiring IFN treatment during the follow-up period
- Known psychotic disorder
- Current substance dependence or abuse (as per DSM-IV criteria) within the past 12 months.